Cross-Linked Polyethylene and Bisphosphonate Therapy for Osteolysis in Total Hip Arthroplasty: A Case Report

Cross-linked polyethylene and bisphosphonate therapy for osteolysis in total hip arthroplasty: a case report.

A 39-year-old woman underwent bilateral total hip arthroplasty with conventional, ethylene oxide-sterilised liners when she was a subject in a radiostereometric analysis study. Within 2 years she had rapid polyethylene wear with aggressive, asymptomatic, and periprosthetic osteolysis on both sides. Oral alendronate therapy halted the progression of osteolysis over a year and revision to cross-l...

Review Article: Polyethylene wear and osteolysis in total hip arthroplasty.

Polyethylene wear has been accepted as a major cause of osteolysis in total hip arthroplasty. Submicron particles, which are secondary to abrasive wear, migrate into the effective joint space and stimulate a foreign-body response resulting in bone loss which is mainly mediated by macrophages. Diagnosis depends on serial radiographic evaluation and frequent follow-up. Polyethylene wear and osteo...

Bisphosphonate treatment for osteolysis in total hip arthroplasty. A report of four cases.

Aseptic loosening due to wear debris is the most frequent modality of failure in total hip arthroplasty. Bisphosphonates, a class of molecules which inhibit bone resorption showed an inhibitory effects on particles-induced osteolysis in vitro and in animal models. We report the clinical, radiographic and densitometric outcome of four postmenopausal women with total hip arthroplasty affected by ...

Alumina-debris-induced osteolysis in contemporary alumina-on-alumina total hip arthroplasty. A case report.

Total Hip Arthroplasty Using Metal Head on a Highly Cross-linked Polyethylene Liner

PURPOSE This retrospective study was performed to evaluate the clinical results and measure polyethylene liner wear in total hip arthroplasty (THA) with highly cross-linked polyethylene. MATERIALS AND METHODS Except for patients who had died or were unable to have follow-up at least 2 years, 60 of 78 hips that underwent THA were included this study. The mean age was 64.5 years (range, 25-81 y...